Center for Addiction Medicine

Tracey Petryshen, PhD

Tracey Petryshen Headshot

Faculty in the Psychiatric Neurogenetics Unit at MGH. Associate Professor of Psychiatry at Harvard Medical School

Contact:     (617) 726-4960


The overarching goal of her research is to elucidate the genetic causes and neural mechanisms underlying psychiatric disorders, primarily schizophrenia and bipolar disorder, and their common comorbidities, particularly addictive disorders, as well as the molecular mechanisms of novel central nervous system active therapeutics. Dr. Petryshen has trained eight post-doctoral research fellows and three pre-doctoral students since 2007 and has sponsored two fellows with NARSAD Young Investigator Awards from the Brain & Behavior Research Foundation and an NINDS K22 Advanced Postdoctoral Career Transition Award. Dr. Petryshen collaborates with Drs. Smoller, Fava, and Evins.


Current Projects

Ventricles, corpus callosum, symptoms & mIR-137 in large N study of schizophrenia

NIMH R21 MH109819 2016 – 18

The goal of this project is to examine the role of the schizophrenia risk gene MIR137 in hallmark structural brain abnormalities in schizophrenia using the GENUS dataset


Molecular links between menarche and changes in the brain in women with migraine

NINDS R21 NS099760 2016 – 18

The goal of this project is to investigate the relationship between migraine in women and molecular genetic influences on pubertal development. Dr. Petryshen directs the genetic association studies


Human iPSC models to bridge gene discovery and neurobiological mechanisms in bipolar disorder

2017 – 18

Harvard Brain Science Initiative

The goal of this project is to link human genetic findings from bipolar disorder genome-wide association studies to the underlying disease neurobiology using human neurons derived from induced pluripotent stem cells (iPSCs) that have been genetically modified to carry single nucleotide polymorphisms that are associated with disease risk.

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