Center for Addiction Medicine

Nikolaos Makris, MD, PhD

Nikolas Makris Headshot

Director of the Center for Morphometric Analysis, the Morphometric Analysis Center Core, co-Director of the Center for Neural Systems investigations at Massachusetts General Hospital Associate Professor of Psychiatry & Neurology, Harvard Medical School

Contact:     (617) 726-5743


Nikos Makris, M.D., Ph.D. is a systems neuroanatomist, imaging scientist, and psychiatrist. He is an Associate Professor of Psychiatry and Neurology in the Departments of Psychiatry and Neurology at Massachusetts General Hospital and Harvard Medical School. He is the Director of the Center for Morphometric Analysis and the MGH Morphometric Analysis Center Core as well as the co-Director of the Center for Neural Systems investigations. He is involved in the integration of projects, scientific and clinical effort, education and training in the domain of neural systems structural and functional anatomy and their applications in basic and clinical neuroscience using imaging. He has published over 200 papers in the neuroscience field.


Current Projects

Effects of curcumin on frontal circuitry in aging monkeys using MRI connectome

NIH/NCCIH 5 R21 AT 008865-02 2016- 18

The goal of this project is to study the effects of Curcumin (natural phenol and the principal curcuminoid of the spice turmeric, member of the ginger family) in the process of senescence.


Neural substrates of diffusion imaging in cognitively aging rhesus monkeys

NIH/NIA&NIMH (BWH) 5 R01 AG 042512-05 2013-18

The major goals of this project is to establish sensitivity of individual diffusion tensor imaging metrics to cognitive maturation and aging, investigate biological underpinnings of diffusion changes and develop free imaging tools to accomplish these goals.


Modulating inhibitory control networks in gambling disorder with theta burst stimulation

NIH/NIDA 1 R21 DA 042271-01A1 2017-19

In this project we will implement multimodal structural magnetic resonance imaging (MRI) and functional MRI methods of analysis in a population of patients affected by gambling disorder undergoing neuromodulation for cognitive control in order to further our understanding in this areas of inquiry.


Patient-specific, effective, and rational functional connectivity targeting for DBS in OCD

NIH/NIMH 1 R01 MH 111917-01A1 2017-20

The goal of this project is a retrospective investigation of imaging-based targeting for Deep Brain Stimulation (DBS) for severe obsessive-compulsive disorder (OCD). We will use anatomic and functional connectivity analyses, plus electrical modeling, to identify white and grey matter zones that must be captured by the electrical stimulation to yield clinical response.


High resolution, comprehensive atlases of the human brain morphology

NIH/NIMH 1 R01 MH 112748-01A1 2017-22

The goal of this project is to generate and disseminate state-of-the-art, high-resolution full brain MR atlases, as the extension of the previous version of the Harvard-Oxford Atlas (HOA), a popular and widely available atlas through FMRIB Software Library (FSL) atlas.

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